{"id":575,"date":"2022-04-09T14:33:23","date_gmt":"2022-04-09T06:33:23","guid":{"rendered":"http:\/\/3d-genome.life\/?page_id=575"},"modified":"2023-02-17T14:26:01","modified_gmt":"2023-02-17T06:26:01","slug":"%e8%b5%84%e6%ba%90","status":"publish","type":"page","link":"http:\/\/3d-genome.life\/?page_id=575","title":{"rendered":"\u8d44\u6e90"},"content":{"rendered":"\n<h3>\u7ec4\u5b66\u79d1\u7814\u5b66\u4e60<\/h3>\n\n\n\n<ul><li><strong>\u63d0\u95ee<\/strong>\uff1a\u5f62\u6210\u81ea\u5df1\u611f\u5174\u8da3\u7684\u79d1\u7814\u65b9\u5411\uff0c\u901a\u8fc7\u641c\u7d22\u9605\u8bfb\u6587\u732e\u548c\u542c\u62a5\u544a\uff0c\u4e86\u89e3\u8fd9\u4e2a\u65b9\u5411\u7684\u524d\u6cbf\u8fdb\u5c55\uff0c\u5173\u6ce8\u6ca1\u6709\u56de\u7b54\u6e05\u695a\u7684\u95ee\u9898\u3002\u5bf9\u8fd9\u4e9b\u95ee\u9898\uff0c\u4f60\u53ef\u4ee5\u63d0\u51fa\u54ea\u4e9b\u65b0\u7684\u751f\u7269\u5047\u8bf4\u6216\u6a21\u578b\uff1f<\/li><\/ul>\n\n\n\n<ul><li><strong>\u7814\u7a76\u65b9\u6848<\/strong>\uff1a\u5c06\u7814\u7a76\u95ee\u9898\u5206\u89e3\u4e3a\u5b50\u95ee\u9898\uff0c\u5bfb\u627e\u5408\u4f5c\u8005\uff0c\u8bbe\u8ba1\u7814\u7a76\u65b9\u6848\uff0c\u5305\u62ec\u4f7f\u7528\u6216\u5f00\u53d1\u524d\u6cbf\u7ec4\u5b66\u6280\u672f\u4ea7\u751f\u6570\u636e\u3001\u6574\u5408\u516c\u5171\u7ec4\u5b66\u6570\u636e\uff08\u5982<a rel=\"noreferrer noopener\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/geo\/\" target=\"_blank\">GEO<\/a>\u3001<a rel=\"noreferrer noopener\" href=\"https:\/\/www.nature.com\/tcga\/\" target=\"_blank\">TCGA\u6570\u636e<\/a>\u3001<a rel=\"noreferrer noopener\" href=\"http:\/\/www.brain-map.org\/\" target=\"_blank\">Allen Brain Atlas<\/a>\uff09\u3001\u5f00\u53d1\u751f\u4fe1\u65b9\u6cd5\u3002<\/li><\/ul>\n\n\n\n<ul><li><strong>\u56de\u7b54<\/strong>\uff1a\u5b9e\u65bd\u548c\u63a8\u8fdb\u7814\u7a76\u65b9\u6848\uff0c\u83b7\u5f97\u5e76\u8d28\u63a7\u7ec4\u5b66\u6570\u636e\u3002 \u5b9a\u671f\u603b\u7ed3\u548c\u8ba8\u8bba\u8bfe\u9898\u8fdb\u5c55\u3001\u96be\u70b9\u3001\u672a\u6765\u8ba1\u5212\uff0c\u4ece\u800c\u56de\u7b54\u3001\u8c03\u6574\u7814\u7a76\u95ee\u9898\u6216\u63d0\u51fa\u65b0\u95ee\u9898\u3002<\/li><\/ul>\n\n\n\n<h3>\u5b66\u4e60\u8d44\u6e90<\/h3>\n\n\n\n<ul><li>\u3010\u5f20\u8d85\u3011<a rel=\"noreferrer noopener\" href=\"https:\/\/github.com\/Czh3\/GADs\" target=\"_blank\">Gene-associated domain (GAD)\u8ba1\u7b97\u548c\u4f5c\u56fe\u4ee3\u7801<\/a><ul><li>\u76f8\u5173\u6587\u732e\uff1a<a rel=\"noreferrer noopener\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32997998\/\" target=\"_blank\">Cell Rep 2020<\/a><\/li><li>\u57fa\u4e8e<a rel=\"noreferrer noopener\" href=\"https:\/\/github.com\/igvteam\/hic-straw\/\" target=\"_blank\">Straw<\/a>\u8ba1\u7b97\u57fa\u56e0\u5185\u90e8\u76f8\u4e92\u4f5c\u7528\u3001R-ggplot2\u4f5c\u56fe<\/li><\/ul><\/li><\/ul>\n\n\n\n<ul id=\"block-5b8b8912-4c41-4a40-962d-dd234cec4732\"><li>\u3010\u5218\u7389\u5a77\u3011<a rel=\"noreferrer noopener\" href=\"https:\/\/github.com\/YutingPKU\" target=\"_blank\">GitHub\u4e3b\u9875<\/a>\uff0c\u5305\u62ecChIP-seq\/RNA-seq\/Hi-C\u6570\u636e\u5904\u7406\u7684\u811a\u672c<ul><li><a rel=\"noreferrer noopener\" href=\"https:\/\/bookdown.org\/ytliu13207\/SingleCellMultiOmicsDataAnalysis\/\" target=\"_blank\">\u5355\u7ec6\u80de\u591a\u7ec4\u5b66\u5206\u6790<\/a>\uff1a\u6d41\u7a0b\u4e0eR\u4ee3\u7801\uff0c\u5305\u62ec\u9884\u5904\u7406\u3001\u53ef\u89c6\u5316\u3001pseudobulk expression\u3001gene signature\u3001DEG\u3001Monocle2\u3001SCENIC<\/li><li>\u63a8\u8350\uff1a\u4e00\u4e2a<a rel=\"noreferrer noopener\" href=\"https:\/\/rafalab.github.io\/pages\/harvardx.html\" target=\"_blank\">Harvard \u8bfe\u7a0b<\/a>\uff0c\u5305\u62ec\u751f\u7269\u6570\u636e\u4e2d\u5e38\u7528\u7684\u7edf\u8ba1\u5206\u6790\u539f\u7406\u548c\u8f6f\u4ef6\uff0c\u8fd8\u6709\u7f16\u7a0b\u57fa\u7840\u6559\u5b66\uff0c\u9002\u5408\u521a\u5165\u95e8\u7684\u540c\u5b66\u5b66\u4e60\u3002\u5305\u62ec\u89c6\u9891\u548c\u8bfe\u4ef6\u3002<br><\/li><\/ul><\/li><li>\u3010\u5415\u94b0\u9e9f\u3011<a href=\"https:\/\/github.com\/sajuukLyu\/Protocols-4pub\" target=\"_blank\" rel=\"noreferrer noopener\">\u4e00\u5957\u7528\u4e8e\u751f\u6210ChIP-seq\u9884\u5904\u7406\u6d41\u7a0b\u811a\u672c\u7684\u4ee3\u7801<\/a><\/li><\/ul>\n\n\n\n<h3>\u6587\u732e\u590d\u73b0<\/h3>\n\n\n\n<p>\u4ece\u611f\u5174\u8da3\u7684\u7814\u7a76\u65b9\u5411\u4e2d\u641c\u7d22\u524d\u6cbf\u6587\u732e\u3002\u9009\u62e9\u4e00\u7bc7\u5206\u6790\u65b9\u6cd5\u6709\u4ee3\u8868\u6027\u3001\u539f\u59cb\u6570\u636e\u53ef\u4e0b\u8f7d\u7684\u8bba\u6587\uff08\u6587\u732e\u9009\u62e9\u89c1\u4e0b\uff0c\u4e5f\u53ef\u5728<a rel=\"noreferrer noopener\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/geo\/\" target=\"_blank\">GEO\u6570\u636e\u5e93<\/a>\u4e2d\u7528\u5173\u952e\u8bcd\u641c\u7d22\uff09\uff1a<\/p>\n\n\n\n<ul id=\"block-6865cc16-73e6-4423-816b-1b9420312e42\"><li><em><strong>Cell<\/strong><\/em>. 2021. 184(3):723-740.e21.\uff08<a href=\"https:\/\/mp.weixin.qq.com\/s\/CTZg60C9CiGdCzlY9HPSFQ\" target=\"_blank\" rel=\"noreferrer noopener\">\u4e2d\u6587\u4ecb\u7ecd<\/a>\uff09<\/li><li><em><strong>Cell Rep<\/strong><\/em>. 2020. 32(13):108206.\uff08<a href=\"https:\/\/mp.weixin.qq.com\/s\/j0q5VvCWpZIhVNsRH0VLIQ\" target=\"_blank\" rel=\"noreferrer noopener\">\u4e2d\u6587\u4ecb\u7ecd<\/a>\uff09<\/li><li><em><strong>Cell Res<\/strong><\/em>. 2022a. 32(1):38-53.\uff08<a href=\"https:\/\/mp.weixin.qq.com\/s\/H92teq7EM57pCBz_fQEdgw\" target=\"_blank\" rel=\"noreferrer noopener\">\u4e2d\u6587\u4ecb\u7ecd<\/a>\uff0c<a href=\"https:\/\/mp.weixin.qq.com\/s\/koyPYmc_W9GcMJmMPoCntQ\" target=\"_blank\" rel=\"noreferrer noopener\">\u4e00\u4f5c\u5386\u7a0b<\/a>\uff09<\/li><\/ul>\n\n\n\n<p>\u4ed4\u7ec6\u9605\u8bfb\u8fd9\u7bc7\u8bba\u6587\u7684\u65b9\u6cd5\u548c\u8865\u5145\u6750\u6599\u4e2d\u7684\u5206\u6790\u65b9\u6cd5\uff0c\u4ece\u5c3d\u53ef\u80fd\u539f\u59cb\u7684\u6570\u636e\u5f00\u59cb\u505a\u6570\u636e\u5904\u7406\u3001\u5206\u6790\u548c\u505a\u56fe\u3002\u76ee\u6807\u662f\u81ea\u5df1\u505a\u51fa\u8bba\u6587\u4e2d\u7684\u5927\u90e8\u5206\u56fe\u8868\u5e76\u4e0e\u5b83\u4eec\u6bd4\u8f83\uff08\u4f8b\u5b50\u89c1\u4e0b\u56fe\uff09\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33155082\/\" target=\"_blank\" rel=\"noopener noreferrer\"><img loading=\"lazy\" width=\"1024\" height=\"775\" src=\"http:\/\/3d-genome.life\/wp-content\/uploads\/2022\/04\/\u6587\u732e\u590d\u73b0-1024x775.png\" alt=\"\" class=\"wp-image-579\" srcset=\"http:\/\/3d-genome.life\/wp-content\/uploads\/2022\/04\/\u6587\u732e\u590d\u73b0-1024x775.png 1024w, http:\/\/3d-genome.life\/wp-content\/uploads\/2022\/04\/\u6587\u732e\u590d\u73b0-300x227.png 300w, http:\/\/3d-genome.life\/wp-content\/uploads\/2022\/04\/\u6587\u732e\u590d\u73b0-768x581.png 768w, http:\/\/3d-genome.life\/wp-content\/uploads\/2022\/04\/\u6587\u732e\u590d\u73b0-1200x908.png 1200w, http:\/\/3d-genome.life\/wp-content\/uploads\/2022\/04\/\u6587\u732e\u590d\u73b0.png 1427w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/a><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>\u7ec4\u5b66\u79d1\u7814\u5b66\u4e60 \u63d0\u95ee\uff1a\u5f62\u6210\u81ea\u5df1\u611f\u5174\u8da3\u7684\u79d1\u7814\u65b9\u5411\uff0c\u901a\u8fc7\u641c\u7d22\u9605\u8bfb\u6587\u732e\u548c\u542c\u62a5\u544a\uff0c\u4e86\u89e3\u8fd9\u4e2a\u65b9\u5411\u7684\u524d\u6cbf\u8fdb\u5c55\uff0c\u5173\u6ce8\u6ca1\u6709\u56de\u7b54\u6e05 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"http:\/\/3d-genome.life\/index.php?rest_route=\/wp\/v2\/pages\/575"}],"collection":[{"href":"http:\/\/3d-genome.life\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/3d-genome.life\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/3d-genome.life\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/3d-genome.life\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=575"}],"version-history":[{"count":22,"href":"http:\/\/3d-genome.life\/index.php?rest_route=\/wp\/v2\/pages\/575\/revisions"}],"predecessor-version":[{"id":904,"href":"http:\/\/3d-genome.life\/index.php?rest_route=\/wp\/v2\/pages\/575\/revisions\/904"}],"wp:attachment":[{"href":"http:\/\/3d-genome.life\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=575"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}